Key result
NOS inhibition reduced peak forearm vascular conductance during contractions more in young adults than in older adults at 20% (-36% vs -23%, P<0.05) and 40% (-35% vs -16%, P<0.05) intensities.
Why the study?
Does NO synthase inhibition reduce contraction-induced rapid vasodilation differently in young versus older adults?
Does NO synthase inhibition reduce contraction-induced rapid vasodilation differently in young versus older adults?
p-value: p=<0.05
The contribution of nitric oxide to contraction-induced rapid vasodilation is greater in young adults and attenuated in older adults.
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Suggests lesser NO reliance for exercise vasodilation with aging; hypothesis-generating for vascular aging mechanisms.
Casey et al. (2013) studied this question. NOS inhibition via N(G)-monomethyl-l-arginine vs. Saline infusion (control) was evaluated on Peak and total vasodilator responses (change in forearm vascular conductance from baseline) (p=<0.05). NOS inhibition reduced peak forearm vascular conductance during contractions more in young adults than in older adults at 20% (-36% vs -23%, P<0.05) and 40% (-35% vs -16%, P<0.05) intensities.
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