Key result
Acetylcholine application to mouse muscle nicotinic receptors revealed a forward rate constant for channel opening of 80,000 s-1 for adult and 60,000 s-1 for fetal receptors.
Population
Quail fibroblast cell lines expressing either the fetal or the adult complement of nicotinic acetylcholine…
Design
Preclinical
Authors
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No immediate clinical implications for neuromuscular therapies; extends kinetic models of developmental nicotinic receptor gating in mice.
The study estimates the channel opening rate of adult and fetal mouse muscle nicotinic receptors, showing a forward rate constant of 80,000 s-1 for adult and 60,000 s-1 for fetal receptors.
Maconochie et al. (1998) studied this question. Acetylcholine was evaluated on Channel opening rate. Acetylcholine application to mouse muscle nicotinic receptors revealed a forward rate constant for channel opening of 80,000 s-1 for adult and 60,000 s-1 for fetal receptors.
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