A simple, selective, and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous determination of Telmisartan and hydrochlorothiazide from pharmaceutical formulation. The mobile phase consisted of methanol and acetonitrile (70:30 v/v) at a flow rate of 1 mL/min and the wavelength of detection was 270 nm. Rabeprazole was used as an internal standard. The retention times of Telmisartan, hydrochlorothiazide and rabeprazole were 1.79±0.01, 2.80±0.01, and 3.19±0.01 minutes, respectively. The developed method was validated according to ICH guidelines. The proposed method can be used for determination of these drugs in combined dosage forms.
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Bhat et al. (2007) studied this question.
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