Key result
Medical therapies including statins, ACE inhibitors, and bisphosphonates are being evaluated to delay aortic stenosis progression, though statins have not proven effective in randomized trials.
Why the study?
Does medical therapy (statins, ACE inhibitors, bisphosphonates) delay the progression of calcific aortic stenosis?
Does medical therapy (statins, ACE inhibitors, bisphosphonates) delay the progression of calcific aortic stenosis?
Current evidence from randomized trials does not support the use of statins to delay the progression of calcific aortic stenosis, while trials for ACE inhibitors and bisphosphonates are ongoing.
Answers are grounded in this paper and cite their sources.
Statins should not be used to slow aortic stenosis progression; trials of ACE inhibitors and bisphosphonates leave the question open.
Severe aortic stenosis due to calcification of the aortic valve is the most common indication for aortic valve replacement in the United States and Europe. The standard therapy for symptomatic patients with severe aortic stenosis is replacement of the valve. Some of the risk factors and pathophysiologic mechanisms in atherosclerosis play an important role in the development of calcific aortic stenosis. In the last few years, there have been an increased number of publications regarding the use of medications in order to delay the progression of aortic stenosis. These medications include statins, angiotensin-converting enzyme inhibitors, and biphosphanates. This article describes and summarizes some of the medical approaches that have emerged to alter the progression of aortic stenosis. Currently, only statins have been evaluated in randomized, placebo-control trials. Furthermore, statins have not proven to alter the progression of aortic stenosis. Ongoing randomized controlled trials with the use of angiotensin-converting enzyme inhibitors, statins, and biphosphonates will determine the use of these medications to delay the progression of aortic stenosis.
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Salas et al. (2011) conducted a review in Calcific Aortic Stenosis. Medical therapy (statins, angiotensin-converting enzyme inhibitors, biphosphanates) was evaluated on Progression of aortic stenosis. Medical therapies including statins, ACE inhibitors, and bisphosphonates are being evaluated to delay aortic stenosis progression, though statins have not proven effective in randomized trials.
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