Key result
Statins and angiotensin converting enzyme inhibitors appear to hold promise for modifying the progression of calcific aortic stenosis, though definitive evidence from large clinical trials is awaited.
Why the study?
Do statins and ACE inhibitors reduce disease progression in patients with calcific aortic stenosis?
Do statins and ACE inhibitors reduce disease progression in patients with calcific aortic stenosis?
Answers are grounded in this paper and cite their sources.
Statins and ACE inhibitors hold theoretical promise for modifying the progression of calcific aortic stenosis, but definitive evidence from large randomized clinical trials is required.
Aortic stenosis is the most common adult heart valve condition seen in the Western world and its incidence continues to rise. No established disease modifying treatments retard progression of the stenotic process. Recent insights into the pathogenesis of calcific aortic stenosis suggest that the disease mimics atherosclerosis. The natural history and progression of calcific aortic stenosis are described with particular emphasis on new and emerging medical treatments that may modify the disease process. In particular, statins and angiotensin converting enzyme inhibitors appear to hold promise but definitive evidence from large clinical trials is awaited.
No takes yet. Share an insight, caveat, or question.
David E. Newby (2006) conducted a review in Aortic stenosis. Statins and angiotensin converting enzyme inhibitors was evaluated. Statins and angiotensin converting enzyme inhibitors appear to hold promise for modifying the progression of calcific aortic stenosis, though definitive evidence from large clinical trials is awaited.
Synapse has enriched 10 related papers. Consider them for comparative context: