The theoretical model demonstrated that the sign of the coupling between voltage and calcium determines whether cardiac cells exhibit concordant alternans, discordant alternans, or quasiperiodic oscillations.
This computational study provides a theoretical framework for understanding the complex coupled dynamics of voltage and calcium in cardiac cells, explaining various modes of instability like alternans.
We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model, and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasiperiodic oscillations of voltage and calcium.
Shiferaw et al. (Tue,) conducted a other in Cardiac arrhythmias (theoretical model). Computational modeling of voltage and calcium coupling was evaluated on Dynamic instability modes (alternans and quasiperiodic oscillations). The theoretical model demonstrated that the sign of the coupling between voltage and calcium determines whether cardiac cells exhibit concordant alternans, discordant alternans, or quasiperiodic oscillations.