Key result
A validated computer model of pulmonary circulation was adapted to simulate pulmonary arterial hypertension and evaluate diagnostic criteria by correlating hemodynamics with vascular compromise.
A computer model of the pulmonary circulation was adapted to simulate PAH and evaluate current diagnostic criteria based on hemodynamics.
Model-based correlations question current PAH hemodynamic thresholds; leaves open need for clinical validation before practice change.
A previously validated computer model of the normal pulmonary circulation is adapted to simulate pulmonary arterial hypertension (PAH) in humans. Model predictions are used to explore the suitability of currently accepted criteria for diagnosing PAH by correlating hemodynamic data with the degree of vascular compromise (disease severity).
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Zoheir Bshouty (2012) studied this question. A validated computer model of pulmonary circulation was adapted to simulate pulmonary arterial hypertension and evaluate diagnostic criteria by correlating hemodynamics with vascular compromise.
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