Key result
Higher platelet MAO activity was observed only in male major depressed patients, with no significant differences across clinical subtypes or DST suppression status.
Why the study?
Is platelet MAO activity associated with clinical subtypes of depression or DST suppression in hospitalized depressed patients?
Observational (n=106)
Is platelet MAO activity associated with clinical subtypes of depression or DST suppression in hospitalized depressed patients?
Platelet MAO activity appears to be related to non-specific factors such as sex and age rather than the diagnosis or clinical subtype of depression.
Higher platelet MAO may be male-specific in major depression; leaves open biomarker utility across sexes or subtypes.
Platelet MAO activity was measured in 75 hospitalized depressed patients and in 31 healthy subjects. Plasmas post dexamethasone cortisol levels were examined in 73 patients. Results indicate that higher platelet MAO activity does not occur in all, but only in male major depressed patients. No relationship between changes of MAO activity and specific clinical subtypes was found. Platelet MAO activity is not different between DST suppressors and DST non suppressors. The authors suggest that platelet MAO activity may be related to non specific factors such as sex, age, but not to diagnosis of depression.
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Poirier et al. (1987) conducted an observational in Depression (n=106). Depression vs. Healthy subjects was evaluated on Platelet MAO activity. Higher platelet MAO activity was observed only in male major depressed patients, with no significant differences across clinical subtypes or DST suppression status.
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