Key result
Preischaemic treatment with 1 nM endothelin-1 significantly reduced infarct size compared to control (14.1% vs. 41.9%) in isolated rat hearts via PKC and KATP channel activation.
Absolute Event Rate: 14.1% vs 41.9%
Preischaemic treatment with endothelin-1 reduces infarct size in isolated rat hearts via ETA receptors, a PKC-dependent mechanism, and KATP channel activation.
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ET-1 may limit infarct size via PKC-KATP; leaves open translation to in vivo or clinical cardioprotection.
Bugge et al. (1996) studied Myocardial infarction. Endothelin-1 (ET-1) vs. Control group was evaluated on Infarct size in % of the risk zone. Preischaemic treatment with 1 nM endothelin-1 significantly reduced infarct size compared to control (14.1% vs. 41.9%) in isolated rat hearts via PKC and KATP channel activation.
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