Key result
Endothelin-1 stimulates InsP3-induced Ca2+ release, which specifically couples to the calcineurin/NFAT pathway to induce cardiac myocyte hypertrophy independently of global Ca2+ elevations.
This study identifies a distinct signaling module where InsP3-induced Ca2+ release, stimulated by ET-1, specifically regulates cardiac myocyte hypertrophy via the calcineurin/NFAT pathway without interfering with contractile Ca2+ fluxes.
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Offers potential to decouple hypertrophy from contractility; hypothesis-generating and requires in vivo validation before clinical consideration.
Higazi et al. (2009) studied Cardiac hypertrophy. Endothelin-1 (ET-1) was evaluated on InsP3-induced Ca2+ release (IICR) and activation of the calcineurin (CnA)/NFAT pathway. Endothelin-1 stimulates InsP3-induced Ca2+ release, which specifically couples to the calcineurin/NFAT pathway to induce cardiac myocyte hypertrophy independently of global Ca2+ elevations.
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