Key result
Hypertrophic stimuli increased the frequency of spontaneous Ca2+ transients and caused calcineurin-dependent nuclear translocation of NFAT in neonatal rat cardiomyocytes.
Absolute Event Rate: 0.62% vs 0.28%
p-value: p=<0.05
Calcineurin-NFAT can act as integrators of the contractile Ca2+ signal and decode alterations in the frequency of rapid Ca2+ oscillations to trigger cardiomyocyte hypertrophy.
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Does not inform clinical hypertrophy management; leaves open frequency-dependent NFAT signaling in adult human cardiomyocytes.
Colella et al. (2008) studied Cardiac cell hypertrophy. Hypertrophic stimuli (Angiotensin II, aldosterone, norepinephrine, KCl) vs. Unstimulated control cells was evaluated on Ca2+ oscillation frequency (Hz) after prolonged aldosterone incubation (p=<0.05). Hypertrophic stimuli increased the frequency of spontaneous Ca2+ transients and caused calcineurin-dependent nuclear translocation of NFAT in neonatal rat cardiomyocytes.
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