Does Contractile Ca 2+ Control Calcineurin-NFAT Signaling and Pathological Hypertrophy in Cardiac Myocytes?
Key result
Evidence supports the hypothesis that calcineurin-NFAT signaling is regulated by contractile Ca2+ transients in cardiac myocytes.
Population
Cardiac myocytes
Design
Review
Authors
Discussion
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Member takes
Implication
Mechanism of calcineurin-NFAT activation amid rhythmic Ca2+ in myocytes remains unclear; leaves open cardiac-specific regulation for targeted study.
Structured PICO
P
Population
Cardiac myocytes
E
Exposure
Contractile Ca2+ transients
O
Outcome
Regulation of calcineurin-NFAT signaling and pathological hypertrophy
This review highlights the potential role of contractile calcium transients in regulating calcineurin-NFAT signaling and pathological hypertrophy in cardiac myocytes.
Cite This Study
Houser et al. (2008) conducted a review in Pathological Hypertrophy in Cardiac Myocytes. Contractile Ca2+ transients was evaluated. Evidence supports the hypothesis that calcineurin-NFAT signaling is regulated by contractile Ca2+ transients in cardiac myocytes.