What question did this study set out to answer?

Examine how cellular components and surfaces regulate blood coagulation beyond traditional protein cascade models.

October 28, 2005Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

What Does It Take to Make the Perfect Clot?

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Authors

DMDougald M. MonroeUniversity of North Carolina at Chapel Hill MHMaureane HoffmanDuke University

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Implication

Review uncovers cell-surface regulation of coagulation pathways in hemostasis, suggesting extrinsic and intrinsic mechanisms act sequentially rather than redundantly.

Key Points

Examine how cellular components and surfaces regulate blood coagulation beyond traditional protein cascade models.
Narrative synthesis of mechanisms underlying hemostasis, thrombosis, and the transition from protein cascade to cell-based coagulation models.
Coagulation functions as overlapping proteolytic reactions coordinated directly on specialized cell surfaces rather than solely through fluid-phase cascades.
Extrinsic and intrinsic pathways perform distinct, non-redundant functions, specifically driving the initiation and propagation phases of clot formation, respectively.

Cite This Study

Monroe et al. (2005) studied this question.

synapsesocial.com/papers/6a6f18dc35aa2c282ce08030 https://doi.org/10.1161/01.atv.0000193624.28251.83

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Implication

Review uncovers cell-surface regulation of coagulation pathways in hemostasis, suggesting extrinsic and intrinsic mechanisms act sequentially rather than redundantly.

What Does It Take to Make the Perfect Clot?

Discussion

Member takes

Implication

Key Points

Cite This Study

What Does It Take to Make the Perfect Clot?

Discussion

Member takes

Implication

Key Points

Cite This Study

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