A population of over 15,000 snuff users and tobacco chewers were observe for cytological, histological, and clinical evaluation. The original observation was for 5 1/2 years. The same group was observed for an additional 4 1/2 years, bringing the total time to ten years. Of the original group of 1,751 patients showing mucosal change, i was able to follow up 1,550. No patient developed carcinoma or serious mucosal changes. From this ten-year study we concluded that snuff, per se, or chewing do not act as carcinogens.
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J. F. Smith (1975) studied this question.
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