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March 11, 2015European Journal of Neuroscience

Evidence for a common biological pathway linking three Parkinson's disease‐causing genes: parkin, PINK1 and DJ‐1

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Authors

CMCelia van der MerweZDZahra Jalali Sefid DashtiACAlan Christoffels

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Merwe et al. (2015) studied this question.

synapsesocial.com/papers/6a6f19ab2163a0a01bc36ffchttps://doi.org/10.1111/ejn.12872
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1<i>Parkin</i> , a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25–q272003 · 312 citations
  2. 2The Parkinson's disease genes <i>pink1</i> and <i>parkin</i> promote mitochondrial fission and/or inhibit fusion in <i>Drosophila</i>2008 · 686 citations
  3. 3PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin2010 · 2,992 citations
  4. 4PINK1 function in health and disease2009 · 155 citations
  5. 5The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization2004 · 1,123 citations