The Lipoprotein Insulin Resistance Index (LP-IR) demonstrated strong correlations with HOMA-IR (r = 0.51) and glucose disposal rate (r = -0.53), outperforming the TGs/HDL-C ratio for identifying insulin resistance.
Observational (n=5,120)
Yes
Does the LP-IR score accurately detect insulin resistance compared to individual lipoprotein parameters or TGs/HDL-C ratio in healthy and diabetic individuals?
The LP-IR score, derived from NMR lipoprotein profiles, strongly correlates with insulin resistance measures and may serve as a simple tool to identify individuals with insulin resistance.
Effect estimate: r = 0.51
p-value: p=<0.001
UNLABELLED: Abstract Background: Lipoprotein particle sizes and concentrations are characteristically altered in patients with insulin resistance (IR) or type 2 diabetes mellitus (T2DM). This study assessed the ability of an IR score, based on nuclear magnetic resonance (NMR)-derived lipoprotein information, to detect IR in otherwise healthy individuals. METHODS: Lipoprotein subclass and size information were evaluated for strength of association with IR, as measured by homeostasis model assessment of insulin resistance (HOMA-IR) in the Multi-Ethnic Study of Atherosclerosis (MESA). To increase the likelihood of identifying subjects with IR, six lipoprotein measures were combined into a single algorithm. The resulting assay Lipoprotein Insulin Resistance Index (LP-IR) was developed using HOMA-IR in 4972 nondiabetic subjects from MESA and verified independently using glucose disposal rates (GDRs) measured during hyperinsulinemic-euglycemic clamps in 56 insulin-sensitive, 46 insulin-resistant, and 46 untreated subjects with T2DM. RESULTS: LP-IR exhibited stronger associations with HOMA-IR (r=0.51) and GDR (r=-0.53) than each of the individual lipoprotein parameters as well as the triglycerides/high-density lipoprotein cholesterol (TGs/HDL-C) ratio (r=0.41 and -0.44, respectively). In MESA, associations between the LP-IR score and HOMA-IR were strong in men (r=0.51), women (r=0.52), European Americans (r=0.58), African Americans (r=0.48), Chinese Americans (r=0.49), and Hispanic Americans (r=0.45). When LP-IR was categorized by HOMA-IR and either body mass index (BMI) or fasting plasma glucose (FPG), subgroups were revealed whose LP-IR scores were high (≥ 50), despite having normal BMIs (<24 kg/m(2)) or FPG (<100 mg/dL). CONCLUSIONS: LP-IR scores had strong associations with multiple measures, HOMA-IR, and GDR, the former being more reflective of hepatic and the latter of peripheral insulin sensitivity, and may represent a simple means to identify individuals with IR.
Shalaurova et al. (Tue,) conducted a observational in Insulin resistance (n=5,120). Lipoprotein Insulin Resistance Index (LP-IR) vs. TGs/HDL-C ratio was evaluated on Correlation with HOMA-IR (r = 0.51, p=<0.001). The Lipoprotein Insulin Resistance Index (LP-IR) demonstrated strong correlations with HOMA-IR (r = 0.51) and glucose disposal rate (r = -0.53), outperforming the TGs/HDL-C ratio for identifying insulin resistance.