Key result
Hemodynamic parameters and biomarkers differentiate pediatric POTS from vasovagal syncope and predict treatment response.
Why the study?
Vasovagal syncope and postural tachycardia syndrome have similar clinical characteristics but require different treatments, and routine therapies have unsatisfactory efficacy due to varying pathomechanisms.
Can biomarkers improve the differential diagnosis and personalized treatment of pediatric vasovagal syncope and postural tachycardia syndrome?
Can biomarkers improve the differential diagnosis and personalized treatment of pediatric vasovagal syncope and postural tachycardia syndrome?
Biomarkers offer a promising approach to accurately differentiate and personalize treatment for children with vasovagal syncope and postural tachycardia syndrome.
May support biomarker-guided differentiation of pediatric POTS versus VVS; hypothesis-generating and requires prospective validation before practice change.
In children, vasovagal syncope and postural tachycardia syndrome constitute the major types of orthostatic intolerance. The clinical characteristics of postural tachycardia syndrome and vasovagal syncope are similar but their treatments differ. Therefore, their differential diagnosis is important to guide the correct treatment. Therapeutic methods vary in patients with the same diagnosis because of different pathomechanisms. Hence, in patients with vasovagal syncope or postural tachycardia syndrome, routine treatments have an unsatisfactory efficacy. However, biomarkers could increase the therapeutic efficacy significantly, allowing for an accurate and detailed assessment of patients and leading to improved therapeutic effects. In the present review, we aimed to summarize the current state of research into biomarkers for distinguishing the diagnosis of pediatric vasovagal syncope from that of postural tachycardia syndrome. We also discuss the biomarkers that predict treatment outcomes during personalized therapy for each subtype.
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Cheng et al. (2022) conducted a review in Postural Tachycardia Syndrome and Vasovagal Syncope. Biomarkers and Hemodynamic Parameters was evaluated. Various hemodynamic parameters and biomarkers can serve as objective indexes to differentiate pediatric postural tachycardia syndrome from vasovagal syncope and predict responses to individualized treatments.
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