Key result
Levenson's criteria detected Neuroleptic Malignant Syndrome in two of three cases of neuroleptic toxicity, and initial treatment with lorazepam provided significant clinical improvement.
Why the study?
Does the use of Levenson's criteria and lorazepam improve the early diagnosis and management of Neuroleptic Malignant Syndrome in patients with neuroleptic toxicity?
Case Report (n=3)
Does the use of Levenson's criteria and lorazepam improve the early diagnosis and management of Neuroleptic Malignant Syndrome in patients with neuroleptic toxicity?
Levenson's criteria and lorazepam may be useful tools for the early diagnosis and management of Neuroleptic Malignant Syndrome.
Answers are grounded in this paper and cite their sources.
May support Levenson's criteria and lorazepam for suspected NMS; hypothesis-generating from case reports and requires prospective validation.
Prompt identification of cases of Neuroleptic Malignant Syndrome (NMS) pose a diagnostic and treatment challenge. Three hospital cases of neuroleptic toxicity were reviewed and compared across five published diagnostic criteria sets for NMS. Of these criteria sets, only Levenson's criteria led to the detection of NMS in two out of our three patients. This criteria set supports a NMS spectrum concept, allowing earlier diagnosis and intervention. Lorazepam was used as initial treatment, which provided significant improvement. Use of Levenson's criteria for early diagnosis of NMS and lorazepam for its treatment may be useful tools for the early management of NMS.
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Pandya et al. (2004) conducted a case report in Neuroleptic Malignant Syndrome (n=3). Levenson's criteria and lorazepam vs. Other diagnostic criteria sets was evaluated on Detection of NMS. Levenson's criteria detected Neuroleptic Malignant Syndrome in two of three cases of neuroleptic toxicity, and initial treatment with lorazepam provided significant clinical improvement.
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