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Provides clinical characteristics, differential diagnosis, and therapeutic guidelines for neuroleptic malignant syndrome based on five cases and a literature review.
The neuroleptic malignant syndrome (NMS) is a rare, life-threatening adverse drug reaction caused by the blockade of central dopaminergic receptors by neuroleptics. Patients most vulnerable to NMS are young males, patients with non-schizophrenic psychosis or organic brain syndrome. The clinical picture, differential diagnosis, and therapeutic guidelines for NMS are discussed, together with five case reports.
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Repo et al. (1989) studied this question.
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