This review provides a contemporary synthesis of the pathobiology, management, and prognosis of neuroleptic malignant syndrome.
May inform NMS management; leaves open prospective validation of prognostic factors.
Neuroleptic malignant syndrome (NMS) is usually a serious neurologic side effect of antipsychotic therapy and characterized by fever, altered mental state, muscular rigidity, and dysautonomia. This chapter provides a contemporary account of NMS, a synthesis of a voluminous and perplexing literature on its pathobiology and management, and gives clear guidelines on the care and prognosis thereafter for patients who develop NMS.
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Buckley et al. (1995) studied this question.
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