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October 23, 2020BJPsych Advances16 citationsOpen Access

Neuroleptic malignant syndrome: a guide for psychiatrists

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Population

Patients with or at risk of Neuroleptic malignant syndrome (NMS)

Design

Review

Key result

Neuroleptic malignant syndrome is a rare, potentially fatal adverse reaction to antipsychotics that requires early recognition, immediate discontinuation of the offending agent, and supportive care.

Authors

OWOvais WadooSOSami OuanesMFMudasir Firdosi

Discussion

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Overview

Neuroleptic malignant syndrome demands prompt acute hospital care; this review leaves open needs for prospective trials on standardized management.

Structured PICO

P
Population
A review of the clinical presentation, diagnosis, and management of neuroleptic malignant syndrome in psychiatric patients.
E
Exposure
Supportive care, medication, and electroconvulsive therapy

Neuroleptic malignant syndrome is a medical emergency requiring prompt recognition and management in an acute hospital setting.

Limitations

  • Lack of large-scale randomized controlled trials for the management of NMS
  • Pathophysiology is not well understood
  • Diagnosis remains clinical and is a diagnosis of exclusion

Cite This Study

Wadoo et al. (2020) conducted a review in Neuroleptic malignant syndrome. Antipsychotics was evaluated. Neuroleptic malignant syndrome is a rare, potentially fatal adverse reaction to antipsychotics that requires early recognition, immediate discontinuation of the offending agent, and supportive care.

synapsesocial.com/papers/6a96b13fa43071aed1f6b1a5https://doi.org/10.1192/bja.2020.71
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