Key result
Intracellular dialysis or injection of anti-ClC-3 antibody completely abolished native volume-sensitive outwardly rectifying anion channel function in cardiac and smooth muscle cells.
Endogenous ClC-3 represents a major molecular entity responsible for native VSOACs in cardiac and smooth muscle cells and Xenopus oocytes.
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ClC-3 may mediate native VSOACs in cardiac and smooth muscle; hypothesis-generating and should not yet change practice.
Duan et al. (2001) studied this question. anti-ClC-3 polyclonal antibody vs. antigen-preabsorbed anti-ClC-3 Ab was evaluated on native volume-sensitive outwardly rectifying anion channel (VSOAC) function. Intracellular dialysis or injection of anti-ClC-3 antibody completely abolished native volume-sensitive outwardly rectifying anion channel function in cardiac and smooth muscle cells.
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