Key result
A review of multiple sclerosis biomarkers found that no single marker currently provides reliable diagnostic and prognostic value with high sensitivity, specificity, and clinical impact.
Why the study?
The search for an ideal multiple sclerosis biomarker with good diagnostic value, prognostic reference, and an impact on clinical outcome has yet to be realized.
What are the frequent biomarkers for multiple sclerosis and their diagnostic, prognostic, and clinical values?
What are the frequent biomarkers for multiple sclerosis and their diagnostic, prognostic, and clinical values?
This review highlights that while two biomarkers are considered gold standards for MS diagnosis, an ideal single biomarker for comprehensive disease management has yet to be identified.
No ideal MS biomarker yet identified; leaves open targeted validation to refine diagnostics and prognostics.
The search for an ideal multiple sclerosis biomarker with good diagnostic value, prognostic reference and an impact on clinical outcome has yet to be realized and is still ongoing. The aim of this review is to establish an overview of the frequent biomarkers for multiple sclerosis that exist to date. The review summarizes the results obtained from electronic databases, as well as thorough manual searches. In this review the sources and methods of biomarkers extraction are described; in addition to the description of each biomarker, determination of the prognostic, diagnostic, disease monitoring and treatment response values besides clinical impact they might possess. We divided the biomarkers into three categories according to the achievement method: laboratory markers, genetic-immunogenetic markers and imaging markers. We have found two biomarkers at the time being considered the gold standard for MS diagnostics. Unfortunately, there does not exist a single solitary marker being able to present reliable diagnostic value, prognostic value, high sensitivity and specificity as well as clinical impact. We need more studies to find the best biomarker for MS.
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Pastare et al. (2019) conducted a review in Multiple Sclerosis. Biomarkers was evaluated. A review of multiple sclerosis biomarkers found that no single marker currently provides reliable diagnostic and prognostic value with high sensitivity, specificity, and clinical impact.
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