January 1, 2008Blood Pressure
Predictors of blood pressure response to intensified and fixed combination treatment of hypertension: The ACCOMPLISH Study
Key result
Combination antihypertensive therapy reduced mean blood pressure from 145.5/80.2 to 132.7/74.7 mmHg at 12 months, with USA region, Caucasian race, and lipid-lowering drugs predicting BP control.
Why the study?
What are the baseline predictors of blood pressure control at 12 months in patients with systolic hypertension receiving combination antihypertensive therapy?
Population
10,173 patients with systolic hypertension (6,132 with diabetes) from the ACCOMPLISH study
Design
Cohort, Blinded baseline and 12-month BP
Follow-up
12 months
Authors
Discussion
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Implication
Supports combination antihypertensive therapy for hypertension; confirms key predictors to guide personalized BP control in practice and trials.
Study Design
Type
RCT (n=10,173)
Blinding
Blinded
Randomization
Randomized
Multicenter
Yes
Structured PICO
What are the baseline predictors of blood pressure control at 12 months in patients with systolic hypertension receiving combination antihypertensive therapy?
P
Population
10,173 patients with systolic hypertension (including 6,132 with diabetes) followed for 12 months to evaluate predictors of blood pressure control.
I
Intervention
Aggressive antihypertensive combination treatment (intensified and fixed combination)
O
Outcome
Blood pressure control (BP <140/90 mmHg overall, <130/80 mmHg for diabetics) and absolute BP value at 12 monthssurrogate
Cite This Study
Kjeldsen et al. (2008) conducted an RCT in Systolic Hypertension (n=10,173). Intensified and fixed combination treatment of hypertension was evaluated on Blood pressure control at 12 months. Combination antihypertensive therapy reduced mean blood pressure from 145.5/80.2 to 132.7/74.7 mmHg at 12 months, with USA region, Caucasian race, and lipid-lowering drugs predicting BP control.