Key result
In patients with COPD, aortic calcification in the abdominal aorta was significantly correlated with increased aortic stiffness (r = 0.34) and inversely related to hip bone mineral density (r = -0.43).
Why the study?
Does aortic calcification correlate with arterial stiffness and bone mineral density in patients with COPD?
Cross-Sectional (n=45)
No
Does aortic calcification correlate with arterial stiffness and bone mineral density in patients with COPD?
Answers are grounded in this paper and cite their sources.
Background: Increased arterial stiffness, using aortic pulse wave velocity (PWV) has been demonstrated in patients with COPD.However, mechanisms underlying this remain unclear.We explored the contribution of aortic calcification to large artery haemodynamics and its association to bone mineral density (BMD) in patients with confirmed COPD.Methods: Patients with COPD, free of maintenance oral corticosteroids, renal disease, diabetes or known cardiovascular disease (n Z 45), 27 male, mean (SD) age 66(7) years underwent unenhanced thoraco-abdominal computed tomography to determine quantitative aortic calcium content using a volume scoring method.Aortic PWV was measured.A subgroup (n Z 29) had BMD determined.Results: All patients had some evidence of aortic calcification.Aortic PWV was related to log 10 calcification in abdominal aorta (r Z 0.34, p Z 0.025) and to semi-quantitative assessment in the ascending and descending thoracic aorta (r Z 0.47 and r Z 0.39, both p < 0.01).Log 10 calcium was inversely related to BMD hip (r Z À0.43), p Z 0.02.Both aortic PWV and log 10 calcium were related to age, which on multiple regression was the independent variable.
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Bolton et al. (2011) conducted a cross-sectional in Chronic Obstructive Pulmonary Disease (COPD) (n=45). Aortic calcification was evaluated on Correlation between abdominal aortic calcification and aortic pulse wave velocity (PWV) (r = 0.34, p=0.025). In patients with COPD, aortic calcification in the abdominal aorta was significantly correlated with increased aortic stiffness (r = 0.34) and inversely related to hip bone mineral density (r = -0.43).
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