Aortic pulse wave velocity was negatively associated with whole body T score (r=-0.23, p=0.014) in peritoneal dialysis patients, but this was no longer significant after adjusting for confounders.
Cross-Sectional (n=118)
Is increased vascular stiffness measured by pulse wave velocity associated with reduced bone mineral density in peritoneal dialysis patients?
The apparent association between increased vascular stiffness and reduced bone mineral density in peritoneal dialysis patients is likely driven by shared confounders such as age and cardiovascular risk factors rather than a direct causal link.
Effect estimate: r=-0.23
p-value: p=0.014
Introduction Vascular stiffness and osteoporosis are independently associated with increased cardiovascular morbidity. We investigated aortic pulse wave velocity (aoPWV), a measure of vascular stiffness, and bone mineral density (BMD) in peritoneal dialysis (PD) patients. Methods AaPWV was measured in patients who had dual energy X-ray absorptiometry (DXA) scans. Results The mean aoPWV was 10.0 ± 0.3 m/s in 118 established PD patients (57.6% male; mean age 64.5 ± 15.3 years. AoPWV was negatively associated with whole body T score r=-0.23, p=0.014, and Z score r=-0.21, p=0.031, left and right leg BMD (r= -0.22, p=0.019; -0.19, p=0.049), and femoral neck BMD (r=-0.18, p=0.047), but not after adjusting aoPWV for age and cardiovascular risk factors. Conclusions Vascular stiffness and osteoporosis increase with age. We report increased vascular stiffness associated with reduced BMD, but after adjusting for confounders, these associations were no longer significant, suggesting an overlapping connection rather than causality. .
Beverstock et al. (Wed,) conducted a cross-sectional in Peritoneal dialysis (n=118). Aortic pulse wave velocity (aoPWV) was evaluated on Association between aortic pulse wave velocity and whole body T score (r=-0.23, p=0.014). Aortic pulse wave velocity was negatively associated with whole body T score (r=-0.23, p=0.014) in peritoneal dialysis patients, but this was no longer significant after adjusting for confounders.