Key result
Arterial stiffness, assessed by measured pulse wave velocity, did not differ significantly between patients treated with peritoneal dialysis (12.1 m/s) and hemodialysis (12.0 m/s).
Why the study?
Does peritoneal dialysis compared to hemodialysis affect arterial stiffness in end-stage renal disease patients?
Cross-Sectional (n=61)
No
Does peritoneal dialysis compared to hemodialysis affect arterial stiffness in end-stage renal disease patients?
Absolute Event Rate: 12.1% vs 12%
p-value: p=NS
Arterial stiffness is equally elevated in end-stage renal disease patients undergoing peritoneal dialysis and hemodialysis, reflecting accelerated arterial aging in both modalities.
Equivalent arterial stiffness across modalities does not guide dialysis choice; leaves open effects on cardiovascular events in end-stage renal disease.
INTRODUCTION: Dialysis patients presents increased arterial stiffness. Results of available studies comparing arterial stiffness in peritoneal dialysis (PD) patients vs hemodialysis (HD) patients are inconsistent. OBJECTIVES: The aim of the study was to compare pulse wave velocity (PWV) in PD and HD patients and to compare value of measured PWV (PWV(M)) with theoretical value of this parameter (PWV(T)) calculated using formula developed by Blacher et al. From the equation it is apparent that PWV increases by 0.8 m/s for each decade of life. PATIENTS AND METHODS: Carotid-femoral PWV(M) was measured in 35 PD and 26 HD patients, using Complior device. In all patients PWV(T) was also calculated. RESULTS: The study groups did not differ significantly with respect to age, gender, and prevalence of diabetes. The value of PWV(M) (PD:12.1 ± 3.3 vs HD:12.0 ± 3.0 m/s) and PWV(T) (PD:10.0 ± 1.4 vs HD:9.9 ± 1.2 m/s) did not differ significantly between PD and HD. PWV(M) was significantly higher than PWVT in both, PD and HD patients. Diastolic blood pressure and mean arterial pressure was higher in PD patients, but systolic blood pressure and pulse pressure did not differ significantly. In PD patients a higher number of antihypertensive medications was used (3 ± 1 vs 2 ± 1;p<0.05). CONCLUSIONS: Arterial stiffness is equally high in peritoneal dialysis patients and in hemodialysis patients. Measured value of PWV in both, PD and HD patients, is significantly higher when compared with theoretical value of PWV. This finding may reflect accelerated arterial aging in patients on dialysis.
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Stróżecki et al. (2011) conducted a cross-sectional in End-stage renal disease (n=61). Peritoneal dialysis vs. Hemodialysis was evaluated on Measured pulse wave velocity (PWVM) (p=NS). Arterial stiffness, assessed by measured pulse wave velocity, did not differ significantly between patients treated with peritoneal dialysis (12.1 m/s) and hemodialysis (12.0 m/s).
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