Key result
Prescription of alfacalcidol was significantly associated with lower aortic pulse wave velocity in haemodialysis patients (β -1.11, p=0.010), suggesting a link to arterial stiffness.
Cross-Sectional (n=303)
Effect estimate: β -1.11
p-value: p=0.010
In haemodialysis patients, arterial stiffness measured by aortic pulse wave velocity is associated with traditional risk factors like systolic blood pressure as well as non-traditional factors such as the prescription of active vitamin D analogues.
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Alfacalcidol prescription was associated with lower aortic stiffness in hemodialysis; hypothesis-generating and requires prospective confirmation before practice change.
Charitaki et al. (2014) conducted a cross-sectional in haemodialysis (n=303). Prescription of active vitamin D analogues (alfacalcidol) was evaluated on Aortic pulse wave velocity (PWV) (β -1.11, p=0.010). Prescription of alfacalcidol was significantly associated with lower aortic pulse wave velocity in haemodialysis patients (β -1.11, p=0.010), suggesting a link to arterial stiffness.
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