Key result
Candesartan cilexetil reduced cardiac and renal damage in the nitric oxide synthase inhibitor model (P<0.05) but increased renal damage in the Dahl salt-sensitive model of hypertension (P<0.05).
Why the study?
Does candesartan cilexetil reduce cardiac and renal damage in salt-sensitive and nitric oxide synthase inhibition-mediated hypertension models?
Population
2 models of hypertension: Dahl salt-sensitive and nitric oxide synthase inhibition-mediated hypertension
Comparison
Candesartan cilexetil at effective and… vs Untreated
Design
Preclinical
Authors
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Differential ARB effects by hypertension etiology warrant caution in salt-sensitive models; leaves open clinical applicability pending human data.
Does candesartan cilexetil reduce cardiac and renal damage in salt-sensitive and nitric oxide synthase inhibition-mediated hypertension models?
p-value: p=<0.05
Angiotensin type 1 receptor blockade reduces end-organ damage in nitric oxide-deficient hypertension but exacerbates renal injury in salt-induced hypertension, suggesting etiology-dependent effects.
Maitland et al. (2006) studied Hypertension (salt-sensitive and nitric oxide synthase inhibition-mediated models). Candesartan cilexetil vs. Untreated was evaluated on Cardiac and renal damage (p=<0.05). Candesartan cilexetil reduced cardiac and renal damage in the nitric oxide synthase inhibitor model (P<0.05) but increased renal damage in the Dahl salt-sensitive model of hypertension (P<0.05).
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