Key result
Various magnetic resonance imaging surrogates exhibit different sensitivities for underlying pathogenic processes of multiple sclerosis, allowing for a comprehensive picture of the degenerative process.
Why the study?
How do various magnetic resonance imaging metrics relate to central nervous system atrophy in multiple sclerosis?
How do various magnetic resonance imaging metrics relate to central nervous system atrophy in multiple sclerosis?
Combining various MRI metrics provides a comprehensive picture of the degenerative process and central nervous system atrophy in multiple sclerosis.
Supports complementary MRI metrics for MS degeneration assessment; leaves open prospective validation before clinical adoption.
This article focuses on the various magnetic resonance imaging metrics currently used in multiple sclerosis and discusses how they relate to central nervous system atrophy. The authors discuss the significance of T2 lesion burden, gray matter damage, T1 hypointense lesions (black holes), contrast‐enhanced lesions, magnetization transfer imaging, diffusion imaging, and magnetic resonance spectroscopy. These magnetic resonance imaging surrogates exhibit different sensitivities for each of the underlying pathogenic processes of multiple sclerosis. By exploiting the complementary nature and varying sensitivities of these magnetic resonance imaging surrogates, it is possible to create a more comprehensive picture of the degenerative process of multiple sclerosis.
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Meier et al. (2004) conducted a review in Multiple Sclerosis. Magnetic resonance imaging surrogates was evaluated. Various magnetic resonance imaging surrogates exhibit different sensitivities for underlying pathogenic processes of multiple sclerosis, allowing for a comprehensive picture of the degenerative process.
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