Key result
Diabetic Mystromys albicaudatus had thicker skeletal muscle capillary basement membranes than nondiabetic controls.
Why the study?
Does spontaneous diabetes increase skeletal muscle capillary basement membrane thickness in Mystromys albicaudatus?
Does spontaneous diabetes increase skeletal muscle capillary basement membrane thickness in Mystromys albicaudatus?
Spontaneously diabetic Mystromys albicaudatus exhibit significant thickening of the skeletal muscle capillary basement membrane, modeling diabetic microangiopathy.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating in diabetic rodents; leaves open human microvascular relevance and clinical translation.
Skeletal muscle capillary basement membrane thickness was determined in age- and sex-matched normal and spontaneously diabetic Mystromys albicaudatus. In nondiabetic animals the average basement membrane thickness was 482.6+/-48.7 A as against 779.0+/-319.9 A in the diabetic ones. This difference was statistically significant at P less than 0.005.
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Yesus et al. (1976) studied this question. Diabetic Mystromys albicaudatus had thicker skeletal muscle capillary basement membranes than nondiabetic controls.
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