Key result
Laser-induced fluorescence spectroscopy emission correlated significantly with plaque growth (R2 = 0.980), vessel narrowing (R2 = 0.964), and cellular invasion (R2 = 0.971) in a rat model.
Why the study?
Can laser-induced fluorescence (LIF) spectroscopy detect transplant vasculopathy in a rat aortic allograft model?
Can laser-induced fluorescence (LIF) spectroscopy detect transplant vasculopathy in a rat aortic allograft model?
Effect estimate: R2 = 0.980 (plaque growth)
p-value: p=<= 0.05
Laser-induced fluorescence spectroscopy can accurately detect intimal plaque development and cellular invasion in a rat model of transplant vasculopathy.
Supports LIF spectroscopy for transplant vasculopathy detection in models; leaves open human translation.
BACKGROUND AND OBJECTIVE: Transplant vasculopathy is a leading cause of late cardiac graft loss. We have examined laser-induced fluorescence (LIF) spectroscopy as an optical diagnostic tool for detection of intimal plaque development and inflammatory cellular invasion in a rat model of aortic allograft transplant. STUDY DESIGN/MATERIALS AND METHODS: Infrarenal aortic segments were transplanted from Lewis to Sprague Dawley rats. A range of vasculopathy development was produced by treatment with a viral anti-inflammatory protein. LIF spectra were recorded from the intima of aortic implants at 28 days. Fluorescence intensity was analyzed for correlation with vasculopathy development. RESULTS: Significant differences in LIF intensity at 400-450 nm (P < or = 0.05 by ANOVA) were detected. LIF emission was correlated with plaque growth (R2 = 0.980), vessel narrowing (R2 = 0.964), and cellular invasion (R2 = 0.971) by regression analysis. CONCLUSION: LIF optical analysis provides a nontraumatic diagnostic approach for detection of atherosclerosis prior to cardiac transplant or during development of vasculopathy after transplant.
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Christov et al. (1999) studied Transplant vasculopathy. Laser-induced fluorescence (LIF) spectroscopy was evaluated on Correlation of LIF emission with plaque growth, vessel narrowing, and cellular invasion (R2 = 0.980 (plaque growth), p=<= 0.05). Laser-induced fluorescence spectroscopy emission correlated significantly with plaque growth (R2 = 0.980), vessel narrowing (R2 = 0.964), and cellular invasion (R2 = 0.971) in a rat model.
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