What does this research mean for the field?

The difference in laser-induced fluorescence spectra between normal and atherosclerotic arteries is primarily driven by their relative elastin and collagen content, allowing for accurate spectral classification of arterial tissue. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

December 1, 1989CirculationOpen Access

Biochemical basis for the difference between normal and atherosclerotic arterial fluorescence.

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Population

Specimens of atherosclerotic aortic plaque and normal aorta, and 182 aortic fluorescence spectra

Comparison

Helium-cadmium laser-induced fluorescence… vs Normal aorta vs atherosclerotic aortic plaque

Design

Preclinical

Authors

LLLarry LaiferAlbert Einstein College of Medicine KOKevin O’BrienRoyal Veterinary College MSM. L. StetzCity College of New York

Discussion

Member takes

Implication

LIF spectroscopy discriminates normal from atherosclerotic aorta in animal models with 92% accuracy; leaves open translation to human intravascular diagnostics.

Structured PICO

Population

Specimens of atherosclerotic aortic plaque (n = 9) and normal aorta (n = 13), and 182 aortic fluorescence spectra

Intervention

Helium-cadmium laser-induced (325 nm) fluorescence spectroscopy

Comparator

Normal aorta vs atherosclerotic aortic plaque

Outcome

Difference in LIF spectra and classification accuracy based on elastin and collagen spectral decompositionsurrogate

Laser-induced fluorescence can accurately discriminate between normal and atherosclerotic aorta based primarily on differences in collagen and elastin content.

Cite This Study

Laifer et al. (1989) studied this question.

synapsesocial.com/papers/6a19b2e5407564563bf66cbe https://doi.org/10.1161/01.cir.80.6.1893

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Implication

LIF spectroscopy discriminates normal from atherosclerotic aorta in animal models with 92% accuracy; leaves open translation to human intravascular diagnostics.

Biochemical basis for the difference between normal and atherosclerotic arterial fluorescence.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Biochemical basis for the difference between normal and atherosclerotic arterial fluorescence.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider