Key result
Administration of parathyroid hormone to nephrectomized, parathyroidectomized rats significantly increased the volume density of cardiac interstitium compared to saline (4.71 vs 1.49, P<0.001).
Why the study?
Does parathyroid hormone (PTH) administration induce cardiac fibrosis in subtotally nephrectomized parathyroidectomized rats?
Does parathyroid hormone (PTH) administration induce cardiac fibrosis in subtotally nephrectomized parathyroidectomized rats?
Absolute Event Rate: 4.71% vs 1.49%
p-value: p=<0.001
Parathyroid hormone plays a permissive role in fibroblast activation and the development of cardiac fibrosis in experimental uremia.
No takes yet. Share an insight, caveat, or question.
May promote cardiac fibrosis in uremic rat models; leaves open PTH modulation as a therapeutic target in CKD.
Amann et al. (1994) studied Uremia and cardiac fibrosis. Parathyroid hormone (rat 1,34 PTH) vs. Saline was evaluated on Volume density of cardiac interstitium (p=<0.001). Administration of parathyroid hormone to nephrectomized, parathyroidectomized rats significantly increased the volume density of cardiac interstitium compared to saline (4.71 vs 1.49, P<0.001).
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: