What question did this study set out to answer?

To examine whether elevated parathyroid hormone directly alters the beating rate, cyclic AMP levels, calcium entry, and survival of cultured heart cells to explain uremic cardiomyopathy.

April 1, 1981Journal of Clinical InvestigationOpen Access

Effect of parathyroid hormone on rat heart cells.

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Authors

EBE. BoginMinistry of Agriculture and Rural Development SMS. G. MassryUniversity of California, Riverside IHI HararyAssaf Harofeh Medical Center

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Implication

In vitro experimental study demonstrates that parathyroid hormone accelerates beating and causes premature death in cultured rat heart cells, suggesting a direct role in uremic cardiomyopathy.

Key Points

To examine whether elevated parathyroid hormone directly alters the beating rate, cyclic AMP levels, calcium entry, and survival of cultured heart cells to explain uremic cardiomyopathy.
Cultured rat heart cells were exposed to intact (1-84), amino-terminal (1-34), and carboxy-terminal (53-84) parathyroid hormone moieties with or without calcium ionophores, verapamil, and adrenergic blockers.
Beating rates, longevity, and cyclic AMP concentrations were tracked over time, and cells were subsequently tested with sera obtained from uremic rats with or without parathyroidectomy.
Intact (1-84) and amino-terminal (1-34) parathyroid hormone elicited an immediate, dose-dependent, and sustained increase in beating rate and accelerated cell death, with intact hormone exerting significantly greater effects.
Parathyroid hormone stimulated rapid and sustained cyclic AMP elevation within 1 minute; its chronotropic effect required calcium, was completely blocked by verapamil, and operated independently of adrenergic receptors.
Sera from uremic rats induced elevated beating rates only if parathyroid glands remained intact or if parathyroidectomized uremic animals received exogenous parathyroid hormone.

Cite This Study

Bogin et al. (1981) studied this question.

synapsesocial.com/papers/6a70590d660549caf2c4edcd https://doi.org/10.1172/jci110137

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Implication

In vitro experimental study demonstrates that parathyroid hormone accelerates beating and causes premature death in cultured rat heart cells, suggesting a direct role in uremic cardiomyopathy.

Effect of parathyroid hormone on rat heart cells.

Discussion

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Implication

Key Points

Cite This Study

Effect of parathyroid hormone on rat heart cells.

Discussion

Member takes

Implication

Key Points

Cite This Study

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