Key result
Coronary artery calcification (HR 1.45; 95% CI 1.11-1.88), carotid intima-media thickness, and ankle-brachial index were each associated with incident stroke beyond established risk factors.
Why the study?
Do coronary artery calcification, carotid intima-media thickness, and ankle-brachial index predict incident stroke in adults without prior stroke or coronary heart disease?
Population
3289 participants of the population-based Heinz Nixdorf Recall study without previous stroke or coronary…
Design
Cohort
Follow-up
9.0±1.9 years
Authors
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May refine stroke risk stratification when combining CAC with CIMT and ABI; leaves open whether integration improves outcomes in trials.
Cohort (n=3,289)
Do coronary artery calcification, carotid intima-media thickness, and ankle-brachial index predict incident stroke in adults without prior stroke or coronary heart disease?
Hazard Ratio: 1.45 (95% CI 1.11–1.88)
CAC, CIMT, and ABI provide complementary information for predicting incident stroke, with the combination of CAC and ABI significantly improving risk discrimination beyond established risk factors.
Gronewold et al. (2014) conducted a cohort in Stroke prediction (n=3,289). Coronary artery calcification, carotid intima-media thickness, and ankle-brachial index was evaluated on Incident stroke (HR 1.45, 95% CI 1.11-1.88). Coronary artery calcification (HR 1.45; 95% CI 1.11-1.88), carotid intima-media thickness, and ankle-brachial index were each associated with incident stroke beyond established risk factors.
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