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Local microRNA-21 mimic delivery emerges as a potential strategy to reduce plaque vulnerability.
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Stabilizing atherosclerotic lesions and preventing plaque ruptures can be seen as the Holy Grail in vascular medicine. In this issue of Molecular Therapy, Jin et al.1 suggest the local delivery of microRNA-21 (miR-21) mimics as a potential therapeutic strategy to reduce plaque vulnerability. Interestingly, inhibition of this microRNA has also been proposed as a therapeutic approach for in-stent restenosis, where the application of anti-miR-21 oligonucleotides on stents improved vessel patency.2
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Barwari et al. (2018) conducted an editorial in Atherosclerotic plaques and in-stent restenosis. microRNA-21 (miR-21) mimics was evaluated. Local delivery of microRNA-21 mimics is suggested as a potential therapeutic strategy to reduce plaque vulnerability, contrasting with anti-miR-21 approaches used for in-stent restenosis.
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