Key result
Higher expression of circulating miR-199b-3p, miR-27b-3p, miR-130a-3p, miR-221-3p, and miR-24-3p was significantly associated with asymptomatic carotid stenosis progression.
Why the study?
Are circulating microRNAs associated with stenosis progression in patients with asymptomatic carotid stenosis?
Population
60 patients with asymptomatic carotid artery stenosis (ACAS) carrying >50% luminal narrowing.
Comparison
Measurement of circulating miRNA expression… vs Patients without ACAS progression
Design
Cohort
Authors
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miRNA panels may flag ACAS progression risk; leaves open clinical utility pending validation.
Cohort (n=60)
Are circulating microRNAs associated with stenosis progression in patients with asymptomatic carotid stenosis?
Specific circulating miRNAs (miR-199b-3p, miR-27b-3p, miR-130a-3p, miR-221-3p, miR-24-3p) are associated with stenosis progression in asymptomatic carotid stenosis, potentially serving as novel biomarkers.
Dolz et al. (2016) conducted a cohort in Asymptomatic carotid artery stenosis (n=60). Circulating miRNAs (miR-199b-3p, miR-27b-3p, miR-130a-3p, miR-221-3p, miR-24-3p) vs. Patients without stenosis progression was evaluated on Asymptomatic carotid artery stenosis progression. Higher expression of circulating miR-199b-3p, miR-27b-3p, miR-130a-3p, miR-221-3p, and miR-24-3p was significantly associated with asymptomatic carotid stenosis progression.
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