Experimental study demonstrates the synthesis of stable discorhabdin A oxa analogues with potent cytotoxicity, suggesting a promising pathway for developing durable marine-derived antitumor agents.
Discorhabdin A (1) exhibits a strong cytotoxic activity in vitro, but it is difficult to synthesize and handle due to the instability of its highly strained N,S-acetal structure. We then designed the analogues of discorhabdin A which also have strong cytotoxic activity and stability. The synthesis and examination of the biological activity of various types of stable discorhabdin A oxa analogues (2) were achieved.
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Wada et al. (2009) studied this question.
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