Key result
Patients with arrhythmic mitral valve prolapse had a higher prevalence of inverted T-waves (OR 2.73; 95% CI 1.85-4.02) and late gadolinium enhancement (RR 4.38; 95% CI 1.77-10.86) than those without.
Why the study?
Mitral valve prolapse is linked to complex ventricular arrhythmias and sudden cardiac death, but parameters identifying patients at higher risk remained to be investigated.
What diagnostic parameters identify mitral valve prolapse patients at higher risk of experiencing complex ventricular arrhythmias?
Population
848 individuals across six studies
Comparison
MVP patients with complex VAs (A-MVP) vs those without (NA-MVP)
Design
Systematic review and meta-analysis
Authors
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ECG and CMR markers may refine arrhythmia risk stratification in mitral valve prolapse; reinforces their role via meta-analytic confirmation.
Meta-Analysis (n=848)
What diagnostic parameters identify mitral valve prolapse patients at higher risk of experiencing complex ventricular arrhythmias?
Odds Ratio: 2.73 (95% CI 1.85–4.02)
p-value: p=<0.00001
Specific ECG, echocardiographic, and CMR parameters, including T-wave inversion, prolonged QTc, bi-leaflet prolapse, mitral annulus disjunction, and late gadolinium enhancement, are significantly associated with complex ventricular arrhythmias in patients with mitral valve prolapse.
Oliveri et al. (2021) conducted a meta-analysis in Mitral valve prolapse (n=848). Complex ventricular arrhythmias (A-MVP) vs. No complex ventricular arrhythmias (NA-MVP) was evaluated on Inverted T-wave on resting ECG (OR 2.73, 95% CI 1.85-4.02, p=<0.00001). Patients with arrhythmic mitral valve prolapse had a higher prevalence of inverted T-waves (OR 2.73; 95% CI 1.85-4.02) and late gadolinium enhancement (RR 4.38; 95% CI 1.77-10.86) than those without.