Key result
Prophylactic interventions, including beta-blockers (OR 0.33; 95% CI 0.26-0.43) and amiodarone (OR 0.43; 95% CI 0.34-0.54), significantly reduced post-operative atrial fibrillation after cardiac surgery.
Why the study?
Do pharmacological and non-pharmacological prophylactic interventions prevent post-operative atrial fibrillation in adult patients undergoing cardiac surgery?
Population
118 RCTs pooling 17,364 adult patients undergoing cardiac surgery
Comparison
Pharmacological and non-pharmacological… vs Control (as defined in the included RCTs)
Design
Meta-analysis
Authors
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Supports routine prophylaxis with beta-blockers or amiodarone after cardiac surgery; confirms efficacy via updated high-level synthesis.
Meta-Analysis (n=17,364)
Do pharmacological and non-pharmacological prophylactic interventions prevent post-operative atrial fibrillation in adult patients undergoing cardiac surgery?
Odds Ratio: 0.33 (95% CI 0.26–0.43)
Prophylactic interventions, including beta-blockers, sotalol, and amiodarone, effectively reduce the incidence of post-operative atrial fibrillation, length of hospital stay, and hospital costs in patients undergoing cardiac surgery.
Arsenault et al. (2013) conducted a meta-analysis in Post-operative atrial fibrillation (n=17,364). Pharmacological and non-pharmacological interventions (e.g., beta-blockers, sotalol, amiodarone, magnesium, atrial pacing) vs. Control was evaluated on Post-operative atrial fibrillation or supraventricular tachycardia (OR 0.33, 95% CI 0.26 to 0.43). Prophylactic interventions, including beta-blockers (OR 0.33; 95% CI 0.26-0.43) and amiodarone (OR 0.43; 95% CI 0.34-0.54), significantly reduced post-operative atrial fibrillation after cardiac surgery.
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