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Nonheme iron-dependent enzymatic reactions play crucial roles in building and modifying bioactive organic molecules in all major classes of natural product pathways. While the enzymes have evolved to use a limited repertoire of protein folding and metal binding sites, the oxidation reactions they catalyze are astonishingly diverse, spanning from complex rearrangements to uncommon bond formation and cleavage reactions. This review summarizes recent discoveries that have significantly expanded our understanding of unusual nonheme iron enzyme catalysis in natural product biosynthesis, covering the literature published between 2017 and August 2022.
Ushimaru et al. (Fri,) studied this question.