MRI-DTI contributes to evaluating diffuse neural injury following repetitive mild traumatic brain injury

Meimei Li; Yan Wang; Zihan Zhang; Yuanyuan Gao; Fanglian Chen; Ping Lei; Xintong Ge

doi:10.1016/j.isci.2025.114221

November 26, 2025iScienceOpen Access

MRI-DTI contributes to evaluating diffuse neural injury following repetitive mild traumatic brain injury

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Key Points

To evaluate diffuse neural injury following repetitive mild traumatic brain injury using MRI-DTI methods.
Utilized F-FDG PET-CT to detect hypometabolism in brain regions
Conducted MRI-DTI analysis with TBSS and VBA approach
Assessed acute pathology following repetitive mild traumatic brain injury
Detected hypometabolism in the thalamus and striatum linked to diffuse neural injury
Established BBB disruption as an early event influencing injury
Demonstrated that MRI-DTI provides a quantitative framework for evaluating acute rmTBI pathology.

Implication

Evaluates diffuse neural injury in mild traumatic brain injury, suggesting early BBB disruption drives pathology.

Abstract

F-FDG PET-CT detected hypometabolism in the thalamus and striatum. These findings position BBB disruption as an early event potentially driving diffuse neural injury, and the combination of TBSS and VBA for MRI-DTI analysis offers a robust quantitative framework for assessing acute rmTBI pathology.

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/6a6f217bfe4101aa97dfb255 https://doi.org/10.1016/j.isci.2025.114221

View Full Paper

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MRI-DTI contributes to evaluating diffuse neural injury following repetitive mild traumatic brain injury

Key Points

Implication

Abstract

Discussion

Cite This Study

MRI-DTI contributes to evaluating diffuse neural injury following repetitive mild traumatic brain injury

Key Points

Implication

Abstract

Discussion

Cite This Study

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