Key result
Preischemic hyperglycemia prolonged the time to ischemic depolarization to 90 s compared to 30 s in hypoglycemia, likely by supporting additional ATP production.
Preischemic hyperglycemia delays ischemic depolarization by supporting additional ATP production, though it leads to greater lactate accumulation and intracellular acidosis.
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May alter ischemic K+ thresholds in models; leaves open clinical translation to stroke.
Ekholm et al. (1993) studied Ischemia. Preischemic hypo- or hyperglycemia vs. Normoglycemia was evaluated on Time to ischemic depolarization. Preischemic hyperglycemia prolonged the time to ischemic depolarization to 90 s compared to 30 s in hypoglycemia, likely by supporting additional ATP production.
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