Key result
Higher preoperative HDL endothelial anti-inflammatory capacity is linked to lower odds of postoperative AKI.
Why the study?
Higher preoperative HDL concentrations associate with less postoperative AKI and animal models show HDL anti-inflammatory capacity reduces ischemic kidney damage, but its relationship with AKI after major surgery in humans is unclear.
Cohort (n=100)
No
In patients with CKD undergoing major cardiac and vascular surgery, higher preoperative HDL anti-inflammatory capacity (which correlates with higher long-term statin doses) is independently associated with a lower risk of postoperative acute kidney injury.
Should not yet change practice; hypothesis-generating for HDL capacity as AKI biomarker in surgical cohorts.
No abstract yet. The journal hasn't published one we can show.
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Perkins et al. (2024) conducted a cohort in Chronic kidney disease undergoing cardiac and vascular surgery (n=100). Higher preoperative high-density lipoprotein (HDL) anti-inflammatory capacity vs. Lower or pro-inflammatory HDL anti-inflammatory capacity was evaluated on Postoperative acute kidney injury (AKI) (OR 0.88, 95% CI 0.80-0.98, p=0.016). Higher preoperative HDL capacity to suppress endothelial ICAM-1 was independently associated with a 12% lower odds of acute kidney injury (OR 0.88) per 10% increase in suppression capacity.
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