Key result
Chronic kidney disease increased the risk of cardiac surgery-associated acute kidney injury and 30-day mortality after cardiovascular surgery.
Why the study?
Cardiovascular mortality increases with decreasing renal function through unknown causes, prompting investigation into whether low chronic inflammation in CKD contributes to increased CAD risk.
Does chronic kidney disease-associated inflammation increase the risk of acute kidney injury and mortality after cardiac surgery in patients with CAD?
Case-Control (n=151)
Does chronic kidney disease-associated inflammation increase the risk of acute kidney injury and mortality after cardiac surgery in patients with CAD?
CKD-associated inflammation, specifically the expansion of proinflammatory CD14++CD16+ monocytes, increases the risk of acute kidney injury and 30-day mortality following cardiac surgery.
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CKD patients show higher CSA-AKI and 30-day mortality risk after cardiac surgery; leaves open whether anti-inflammatory strategies alter prognosis.
Casas et al. (2020) conducted a case-control in Coronary artery disease and chronic kidney disease (n=151). Chronic kidney disease (CKD) vs. Without CKD was evaluated on Cardiac surgery-associated acute kidney injury (CSA-AKI) and 30-day mortality. Chronic kidney disease increased the risk of cardiac surgery-associated acute kidney injury and 30-day mortality after cardiovascular surgery.
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