Key result
Persistent hyponatremia in patients hospitalized with severe heart failure was associated with increased 6-month all-cause mortality compared to normonatremia (31% vs 16%; HR 1.82, P=0.04).
Why the study?
Does persistent hyponatremia predict mortality and rehospitalization in patients hospitalized with severe heart failure?
Cohort (n=433)
Does persistent hyponatremia predict mortality and rehospitalization in patients hospitalized with severe heart failure?
Hazard Ratio: 1.82
Absolute Event Rate: 31% vs 16%
p-value: p=0.04
Persistent hyponatremia is an independent predictor of increased mortality and heart failure rehospitalization in patients with severe heart failure, regardless of clinical and hemodynamic improvements.
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Persistent hyponatremia signals higher post-discharge risk in severe HF; leaves open whether targeted correction improves outcomes.
Gheorghiade et al. (2007) conducted a cohort in Severe Heart Failure (n=433). Persistent hyponatremia vs. Normonatremia was evaluated on 6-month all-cause mortality (HR 1.82, p=0.04). Persistent hyponatremia in patients hospitalized with severe heart failure was associated with increased 6-month all-cause mortality compared to normonatremia (31% vs 16%; HR 1.82, P=0.04).
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