Key result
Decreasing renal function was associated with a graded increase in all-cause mortality, reaching an HR of 3.38 (95% CI 2.73-4.19) for severe renal impairment compared to normal function.
Why the study?
Is estimated glomerular filtration rate (eGFR) associated with mortality and cardiac death in patients with known or suspected coronary artery disease?
Population
6447 patients with known or suspected coronary artery disease
Comparison
Mild, moderate, and severe renal impairment vs Normal renal function
Design
Cohort
Follow-up
mean 7 years
Authors
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Renal impairment signals higher mortality in CAD; supports risk stratification but leaves causal effects and intervention benefits open.
Cohort (n=6,447)
Is estimated glomerular filtration rate (eGFR) associated with mortality and cardiac death in patients with known or suspected coronary artery disease?
Hazard Ratio: 3.38 (95% CI 2.73–4.19)
Renal function is a graded and independent predictor of long-term mortality in patients with known or suspected coronary artery disease, highlighting the need for intense treatment and close surveillance in this population.
Domburg et al. (2008) conducted a cohort in Known or suspected coronary artery disease (n=6,447). Renal impairment (decreased eGFR) vs. Normal renal function was evaluated on All-cause mortality (HR 3.38, 95% CI 2.73-4.19). Decreasing renal function was associated with a graded increase in all-cause mortality, reaching an HR of 3.38 (95% CI 2.73-4.19) for severe renal impairment compared to normal function.
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