What question did this study set out to answer?

December 1, 1960Immunology and Cell Biology

Changes in Polarisation Resistance During the Repolarisation Phase of the Rabbit Ventricular Action Potential

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Population

74 fibres in 7 preparations of rabbit ventricular muscle

Comparison

Measurement with intracellular double-barrelled… vs Resting polarisation resistance

Design

Preclinical

Authors

EJEA JohnsonUniversity of Wisconsin–Madison JTJ. TilleMonash University

Discussion

Member takes

Implication

Increased polarization resistance during repolarization in rabbit fibers warrants clinical caution; leaves open relevance to human ventricular electrophysiology.

Key Points

To measure the changes in polarisation resistance during the repolarisation phase of rabbit ventricular action potentials.
Examined action potentials from 74 fibres across 7 preparations using intracellular double-barrelled microelectrodes.
Measured the magnitude and time course of polarisation resistance.
Analyzed the effects of large negative voltage displacements (60 mV) on resistance measurements.
Observed that polarisation resistance exceeded resting values at some point during repolarisation.
Mean maximum increase in polarisation resistance was 1.63 (± 0.15 S.D.) times above resting value.
No evidence of regenerative repolarisation was found.

Structured PICO

Population

74 fibres in 7 preparations of rabbit ventricular muscle

Intervention

Measurement with intracellular double-barrelled microelectrodes and negative voltage displacements

Comparator

Resting polarisation resistance

Outcome

Magnitude and time course of changes in polarisation resistance during the repolarisation phase of action potentialssurrogate

This preclinical study demonstrates that polarisation resistance increases during the repolarisation phase of the rabbit ventricular action potential compared to resting state.

Cite This Study

Johnson et al. (1960) studied this question.

synapsesocial.com/papers/6a6f22f6a7fbea1e4407abc8 https://doi.org/10.1038/icb.1960.56

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Implication

Increased polarization resistance during repolarization in rabbit fibers warrants clinical caution; leaves open relevance to human ventricular electrophysiology.

Changes in Polarisation Resistance During the Repolarisation Phase of the Rabbit Ventricular Action Potential

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Changes in Polarisation Resistance During the Repolarisation Phase of the Rabbit Ventricular Action Potential

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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