Key result
In adults with type 2 diabetes, the CETP Taq1B B1B1 genotype was associated with a lower LDL/HDL ratio (P<0.001) and triglycerides when consuming diets with higher insulin indices, counteracting diet-induced CVD risk.
Why the study?
Gene-diet interactions may contribute to inter-individual variation in cardiovascular risk factors, prompting an examination of how CETP TaqB1 polymorphism interacts with dietary insulin index and load in T2DM patients.
Does CETP TaqB1 polymorphism interact with dietary insulin index and load to alter cardiovascular risk factors in type 2 diabetic adults?
Cross-Sectional (n=220)
No
Does CETP TaqB1 polymorphism interact with dietary insulin index and load to alter cardiovascular risk factors in type 2 diabetic adults?
p-value: p=<0.001
The CETP Taq1B B1 allele may counteract the cardiovascular risk induced by high dietary insulin index and load in patients with type 2 diabetes.
May inform personalized dietary strategies in T2D; hypothesis-generating and should not yet change practice.
Gene-diet interactions may play an important role in the inter individual diversity observed in on cardiovascular disease (CVD) risk factors. Therefore, in the current study, we examined the interaction of CETP TaqB1 polymorphism with dietary insulin index and load (DII and DIL), in altering on CVD risk factors among type 2 diabetes mellitus (T2DM). In this cross-sectional study, blood samples were collected from 220 type 2 diabetic patients (134 females and 86 male) with a mean age of 52.24 years in Tehran, Iran. DIL and DII were obtained via validated food-frequency questionnaire (FFQ). Taq1B polymorphism was genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Biochemical markers including total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), superoxide dismutase (SOD), C-reactive protein (CRP), total antioxidant capacity (TAC), pentraxin-3 (PTX3), isoprostaneF2α (PGF2α). interleukin 18 (IL18), leptin and ghrelin were measured by standard protocol. Patients with B1B1 genotype had lower lipid profiles include LDL/HDL (P < 0.001) and TG (P = 0.04) when they consumed diets higher on the DIL and DII index. Moreover, carriers of B2B2 genotype who were in the last tertile of DIL had higher antioxidant and inflammatory markers include SOD (P = 0.01), PGF2α (P = 0.04) and CRP (P = 0.02). Further, a significant interaction between CETP TaqB1 and DII was shown in terms of WC (P = 0.01), where the highest WC were observed in B2B2 genotype carriers following a DII score. However, the highest inflammatory and antioxidant markers include CRP (P = 0.04), TAC (P = 0.01), SOD (P = 0.02), and PGF2α (P = 0.02) were observed in B2B2 genotype carriers when they consumed diets higher on the DII index. Based on the current study, it could be proposed that CETP polymorphism may be associated with CVD risk factors in T2DM patients with high following insulin indices, including DII and DIL. It seems that CETP Taq1B polymorphism can invert the result produced by insulin. This conclusion illustrates that the CETP Taq1B B1 allele could counteract the CVD risk induced by high DII and DIL.
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Abaj et al. (2021) conducted a cross-sectional in Type 2 diabetes mellitus (n=220). CETP Taq1B polymorphism and dietary insulin index/load vs. Lower dietary insulin index/load and other genotypes was evaluated on Interaction between CETP Taq1B polymorphism and dietary insulin load on LDL/HDL ratio (p=<0.001). In adults with type 2 diabetes, the CETP Taq1B B1B1 genotype was associated with a lower LDL/HDL ratio (P<0.001) and triglycerides when consuming diets with higher insulin indices, counteracting diet-induced CVD risk.
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